Stem cells are known for their self-renewal capacity and their transformation into different cells. They are found in embryonic, fetal, and adult tissue. The fat deposition in adipose tissue establishes it as an energy reservoir and thermal insulator.

Adipose tissue also contains the population of mesenchymal stem cells that can form adipocytes, osteoblasts, myocytes, and chondrocytes.

Adipose tissue-derived stem cells are especially popular due to the widespread presence of the tissue in the body, less painful extraction of stem cells, and ability to harvest stem cells in large quantities.

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The research on primary cells has been generating substantial insights. Primary cells are directly obtained from the homogenization of the tissue. They retain molecular and functional characteristics of the tissue, rendering them as an appropriate model for in vitro research on tissue-based responses. Their application extends into the drug discovery process, toxicity screening, 3D culture, graft formation, understanding disease pathophysiology, cell signaling, etc.

Primary cells extracted from a particular species are helpful in the translation of the in vitro research result into the corresponding animal model of that species.

At Kosheeka, we deliver various tissue specific primary cells from liver, skin, reproductive system, etc. We offer human primary cells as well as primary cells from different strains of mice. All our primary cells are provided at low passage number after robust quality checks by a team of trained personnel.

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Primary cells are directly derived from the tissue. They are identical to the tissue of origin in their genotypic and phenotypic characteristics. The immortalized cell lines lose their similarity to the tissue owing to genetic changes, thus rendering primary cells as preferable options for preclinical studies. Numerous primary cells derived from tissues such as liver, skin, bone marrow, endothelium, etc., have optimized protocols and media composition. These primary cells provide key insights into the gene expression and signaling mechanisms. They utilization in 3D culture to form a tissue model offering an alternative with better representation of the in vivo environment.

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Unlock the future of discovery with Rat Bone Marrow Derived Mesenchymal Stem Cells Immuno Deficient and Rat Bone Marrow Derived Mononuclear Cells—crafted like nature’s own blueprint in our GMP-compliant labs. These cellular treasures, vital for unraveling mysteries in basic and applied sciences, are sourced ethically for researchers worldwide. Think of us as the alchemists of biomedical progress, transforming possibilities into precision tools for breakthroughs. From human origins to preclinical animal models, our primary cells bridge curiosity and innovation. Curious minds, dial +91-9654-321-400 for quotes or insights—your next discovery could be just a call away. Science begins where our cells live.

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The epithelium is the outer layer that protects the tissues from the external environment. Therefore, it is present in the skin, gastrointestinal tract, lungs, etc. Initially, endothelium, present in blood vessels and lymphatic vessels, was thought to be a type of epithelial layer, but numerous studies marked a clear distinction between both cells.

• All three germ layers form epithelial cells, whereas endothelial cells originate from mesoderm.
• Epithelial cells always form a continuous barrier over the tissue, while the endothelium can vary from a continuous to a discontinuous surface, depending on the underlying tissue.
• Epithelial cells are involved in functions such as protection of the tissue, transport of nutrients across tissue, and secretion of hormones. Endothelial cells regulate the traffic of cells and other biomolecules between vessels and tissue, control vasodilation, prevent coagulation, and mediate inflammation.
• Epithelial cells are mostly applied in cancer research, wound healing, drug transport, toxicity studies, etc. After the exploitation of endothelial structure in tumour therapy, endothelial cells gained more attention. Presently, they are used to study inflammation, hypertension, tissue-specific changes, vasculogenesis, angiogenesis, and cardiovascular diseases.

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