It's essential to discuss any concerns or potential side effects with your healthcare provider before starting treatment with Zenegra 50 mg. Individuals with certain underlying medical conditions or taking other medications should consult with their healthcare provider before using this medication, as it may interact with other drugs or exacerbate certain health conditions. Additionally, it's important to avoid consuming alcohol or grapefruit juice while taking Zenegra 50 mg, as they may interact and increase the risk of side effects.